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Protein phosphatase 2A regulatory subunits and cancer

Pieter J A Eichhorn1, Menno P Creyghton, René Bernards

  • 1Division of Molecular Carcinogenesis, Center for Cancer Genomics and Center for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Biochimica Et Biophysica Acta
|July 1, 2008
PubMed

Insights

Protein phosphatase 2 (PP2A) holoenzymes regulate key cancer pathways. This review highlights PP2A

Area of Science:

  • Molecular biology
  • Biochemistry
  • Oncology

Background:

  • Serine/threonine protein phosphatase (PP2A) is a crucial trimeric enzyme involved in cellular signaling.
  • PP2A holoenzyme activity and specificity are modulated by regulatory B subunits.
  • Deregulation of PP2A-controlled pathways is implicated in cancer development.

Purpose of the Study:

  • To review the role of specific PP2A holoenzymes in cancer.
  • To summarize PP2A's function in cancer-relevant signaling pathways.
  • To highlight PP2A's tumor suppressor activities.

Main Methods:

  • Literature review of PP2A function in cancer.
  • Analysis of PP2A's role in MAPK signaling.
  • Analysis of PP2A's role in Wnt signaling.

Main Results:

  • PP2A acts as a tumor suppressor.
  • Specific PP2A holoenzymes influence major signaling pathways.
  • PP2A regulates MAPK and Wnt signaling pathways.

Conclusions:

  • PP2A holoenzymes are critical regulators in cancer.
  • Understanding PP2A function offers therapeutic potential for cancer treatment.

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