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Related Experiment Video

Updated: Jul 4, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Update on fibromyalgia therapy.

Micha Abeles1, Bruce M Solitar, Michael H Pillinger

  • 1Division of Rheumatology, Department of Medicine, The University of Connecticut School of Medicine, Farmington, USA. aabeles@uchc.edu

The American Journal of Medicine
|July 1, 2008
PubMed
Summary
This summary is machine-generated.

Fibromyalgia is a chronic pain condition with unclear causes, often involving widespread pain and fatigue. This review examines treatments from 1970-2007, finding limited success with current options.

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Published on: July 14, 2018

Area of Science:

  • Rheumatology
  • Pain Medicine
  • Clinical Pharmacology

Background:

  • Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and psychological distress.
  • Its exact cause remains unclear, but central pain processing dysfunction is implicated in its pathogenesis.
  • Current pharmacological treatments for fibromyalgia have shown limited efficacy, with only one FDA-approved drug available.

Purpose of the Study:

  • To systematically review and critically evaluate clinical investigations of both medicinal and nonmedicinal treatments for fibromyalgia.
  • To assess the effectiveness of various therapeutic interventions for fibromyalgia syndrome.

Main Methods:

  • Systematic literature review of clinical investigations.
  • Evaluation of studies on fibromyalgia treatments published between 1970 and 2007.
  • Analysis of both pharmacological and non-pharmacological interventions.

Main Results:

  • No single drug or drug class has demonstrated consistent, widespread efficacy for fibromyalgia patients.
  • Limited evidence supports the effectiveness of many studied treatments.
  • The review covers a broad range of interventions evaluated over several decades.

Conclusions:

  • Despite extensive research, effective treatments for fibromyalgia remain limited.
  • Further research is needed to identify and validate successful therapeutic strategies for fibromyalgia.
  • The review highlights the ongoing challenges in managing this complex chronic pain condition.