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Updated: Jul 4, 2026

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

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Perspectives on "chronic Lyme disease".

Phillip J Baker¹

¹American Lyme Disease Foundation, Lyme, Connecticut, USA. inquire@aldf.com

The American Journal of Medicine

|July 1, 2008

Summary

Controversy surrounds chronic Lyme disease and posttreatment Lyme disease syndrome. Extended antibiotic therapy for these conditions lacks evidence and poses significant risks, including death.

Area of Science:

Infectious Diseases
Clinical Medicine
Medical Research

Background:

Significant controversy exists regarding the treatment of Lyme disease, specifically concerning poorly defined conditions like chronic Lyme disease and posttreatment Lyme disease syndrome.
These conditions are often mistakenly attributed to persistent Borrelia burgdorferi infection.

Purpose of the Study:

To review current clinical research on chronic Lyme disease and posttreatment Lyme disease syndrome.
To provide evidence-based information to aid physicians and lawmakers in making safe and sound treatment decisions.

Main Methods:

Literature review of existing clinical research.
Analysis of evidence regarding persistent infection in chronic Lyme disease and posttreatment Lyme disease syndrome.

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Main Results:

Absence of direct clinical evidence supporting persistent infection as the cause of these syndromes.
Identification of potential harms associated with prolonged antibiotic therapy, including a reported death.

Conclusions:

Extended antibiotic therapy for chronic Lyme disease and posttreatment Lyme disease syndrome is not supported by current clinical evidence.
Physicians and policymakers should exercise caution and rely on evidence-based practices to ensure patient safety and avoid unnecessary harm.