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Updated: Jul 4, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
Published on: October 7, 2021
Demyelinating sensorimotor polyneuropathy associated with the use of sirolimus: a case report
M Bilodeau1, Z Hassoun, D Brunet
1Service d'hépatologie, Hôpital Saint-Luc du CHUM, Montréal, Québec, Canada. Marc.Bilodeau@umontreal.ca
Abstract:
Liver transplantation is associated with a number of neurological complications. We herein report a case of chronic inflammatory demyelinating polyneuropathy associated with the use of sirolimus-based immunosuppression. The patient was treated by converting the immunosuppression from sirolimus to cyclosporine and by a short course of oral steroids. Following this, we observed almost complete clinical and electrophysiologic resolution of this syndrome. We believe that this is the first described case of such a complication occurring in association with sirolimus. This immunosuppressive agent can, therefore, lead to neurological complications similar to the ones that have been observed with calcineurin inhibitors.
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