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Published on: February 12, 2017
[Management of targeted molecular therapies toxicities in thoracic cancerology]
1Département de Médecine, Institut Gustave-Roussy, 39 Rue Camille-Desmoulins, 94800 Villejuif, France.
Abstract:
Targeted molecular therapies, mainly enzyme inhibitors and humanized antibodies, are being widely developed, especially in the area of lung cancer. Though often considered to be better tolerated than conventional cytotoxic chemotherapies, targeted molecular therapies induce specific toxicities that may have detrimental effects on the quality of life. We sum up various toxicities from targeted treatment available for lung cancer in France with the aim of improving their prevention, diagnosis and management.
Insights
Targeted therapies for lung cancer, like enzyme inhibitors and antibodies, offer benefits but cause unique side effects. This review details these toxicities to improve patient care and quality of life.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Context:
- Lung cancer treatment landscape is evolving with targeted molecular therapies.
- These therapies include enzyme inhibitors and humanized antibodies.
- While often better tolerated than chemotherapy, they present distinct toxicities.
Purpose:
- To summarize toxicities associated with targeted lung cancer treatments.
- To provide a basis for improved prevention, diagnosis, and management of these adverse events.
- To enhance the quality of life for patients undergoing targeted therapy.
Summary:
- Targeted molecular therapies are increasingly used for lung cancer.
- Specific toxicities arise from these treatments, impacting patient well-being.
- This review consolidates information on these toxicities in the French context.
Impact:
- Aims to guide clinicians in managing targeted therapy side effects.
- Contributes to optimizing patient care and quality of life in lung cancer treatment.
- Facilitates better understanding and handling of adverse events from novel lung cancer drugs.
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