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Related Experiment Videos

Left ventricular-arterial coupling in conscious dogs.

W C Little1, C P Cheng

  • 1Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

The American Journal of Physiology
|July 1, 1991
PubMed
Summary

Optimizing left ventricular (LV) stroke work (SW) requires matching arterial elastance (EA) to LV end-systolic elastance (EES). Maximum SW occurs when EES equals EA, but a broad plateau exists, indicating functional reserve in LV-arterial coupling.

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Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering

Background:

  • The interaction between the left ventricle (LV) and the arterial system is crucial for efficient cardiac function.
  • Understanding the criteria for optimal coupling is essential for diagnosing and treating cardiovascular diseases.

Purpose of the Study:

  • To determine the relationship between left ventricular (LV) stroke work (SW) and the coupling of the LV with the arterial system.
  • To investigate the criteria for maximizing SW and the efficiency of transforming LV pressure-volume area (PVA) to SW.

Main Methods:

  • Studied eight conscious dogs instrumented for LV pressure and volume measurements.
  • Determined LV end-systolic pressure-volume (PES-VES) relation and its slope (EES).
  • Compared EES with arterial elastance (EA) under various pharmacological interventions.

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Main Results:

  • Maximum LV SW occurred when EES/EA ratio was approximately 1.
  • SW remained near maximal within a broad range of EES/EA (0.56-2.29).
  • The conversion of LV PVA to SW increased with increasing EES/EA.

Conclusions:

  • Optimal LV-arterial coupling for maximum SW occurs when EES equals EA.
  • The LV-arterial system exhibits a broad plateau for SW, with significant decreases only when EA greatly exceeds EES.
  • Analysis of LV-arterial coupling in the pressure-volume plane is supported by these findings.