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Updated: Jul 4, 2026

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
Published on: January 12, 2016
Cortical atrophy and white matter hyperintensities in HIV: the Hawaii Aging with HIV Cohort Study
Aaron McMurtray1, Beau Nakamoto, Cecelia Shikuma
1Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI. aaronmnm@hawaii.edu
Background:
As many human immunodeficiency virus (HIV)-seropositive individuals are now living longer after infection because of highly active antiretroviral therapy, aging-related manifestations of cerebral small-vessel ischemic vascular disease, such as brain white matter hyperintensities (WMHs), are becoming increasingly important in this population.
Goals:
This study was designed to determine the relationship between WMHs and cortical volumes in HIV-seropositive individuals.
Materials And Methods:
Voxel-based morphometry was used to compare cortical volumes among 62 HIV-seropositive individuals participating in the Hawaii Aging with HIV Cohort Study, 30 with moderate WMHs and 32 with minimal or no WMHs.
Results:
Presence of moderate WMHs was associated with decreased cortical volumes in the frontal lobes bilaterally.
Conclusion:
These findings suggest that age-related WMHs are associated with reduced frontal gray matter volumes in HIV-seropositive individuals, supporting the hypothesis that the frontal lobes may have greater susceptibility to the effects of small-vessel ischemic vascular disease.
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