Depression in patients with Parkinson's disease: impact on functioning
Florindo Stella1, Claudio E M Banzato, Elizabeth M A Barasnevicius Quagliato
1Biosciences Institute, Campus of Rio Claro, UNESP-Sao Paulo State University, Brazil. fstella@rc.unesp.br
Journal of the Neurological Sciences
|July 1, 2008
Summary
Depression is common in Parkinson's disease (PD). This study found depressed PD patients have worse symptoms and reduced functional capacity, indicating depression worsens the PD burden.
Area of Science:
- Neuroscience
- Psychiatry
- Movement Disorders
Background:
- Depression is a frequent neuropsychiatric symptom in Parkinson's disease (PD).
- It is increasingly viewed as an intrinsic manifestation of PD.
- Understanding its impact on PD progression and patient burden is crucial.
Purpose of the Study:
- To investigate the relationship between depression and clinical aspects of Parkinson's disease.
- To assess how co-occurring depression impacts the overall burden of PD.
- To analyze clinical data of PD patients with and without depression.
Main Methods:
- Fifty idiopathic PD outpatients were evaluated using Hoehn & Yahr staging (H&Y), UPDRS, and Schwab & England (S&E) scales.
- Psychiatric assessment included ICD-10 criteria and Montgomery-Asberg Depression Scale.
- Statistical analysis involved descriptive statistics, linear regression, T-tests, and ANOVA.
Main Results:
- 34% of PD patients were diagnosed with clinical depression.
- Depressed patients exhibited more advanced H&Y staging, higher UPDRS scores, and lower S&E functional capacity.
- No significant difference in PD duration was observed between depressed and non-depressed groups.
Conclusions:
- Depression is significantly associated with poorer clinical status and reduced functional capacity in Parkinson's disease patients.
- These findings support the hypothesis that depression is an integral component affecting PD patient outcomes.
- Addressing depression is vital for managing the overall burden in Parkinson's disease.
Related Concept Videos
01:24Parkinson's Disease: Treatment
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
01:15Parkinson's Disease: Overview
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
01:24Parkinson Disease ll: Pathophysiology
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
01:24Parkinson Disease l: Introduction
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
01:11Alterations in Muscle Tone lll
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
01:27Depressive Disorders: MDD and Dysthymia
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...