Related Experiment Video
Updated: Jul 4, 2026

A Modified Inflammatory Pain Model to Study the Analgesic Effect in Mice
Published on: November 15, 2024
[Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex]
Jun-Jun Zhou1, Yuan-Xu Jiang, Shao-Ju Jin
1Department of Pharmacology, Ningxia Medical College, Yinchuan 750004, China.
Objective:
To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).
Method:
Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.
Result:
Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.
Conclusion:
The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).
Related Concept Videos
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Opioid Analgesics: Morphine and Other Natural Cogeners
Opioid Receptors: Overview
Cholinergic Antagonists: Pharmacokinetics
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...