Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A system model for closed-circuit inhalation anesthesia. I. Computer study.

J G Lerou1, R Dirksen, H H Beneken Kolmer

  • 1Institute for Anesthesiology, University of Nijmegen, The Netherlands.

Anesthesiology
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium].

Der Anaesthesist·2008
Same author

Comparison of the effects and disposition kinetics of lidocaine and (+/-)prilocaine in patients undergoing axillary brachial plexus block during day case surgery.

Clinical drug investigation·2008
Same author

Reduction of blood loss using high-dose aprotinin in major orthopaedic surgery.

The Journal of bone and joint surgery. British volume·2004
Same author

COX 2 selectivity of non-steroidal anti-inflammatory drugs and perioperative blood loss in hip surgery. A randomized comparison of indomethacin and meloxicam.

European journal of anaesthesiology·2003
Same author

Does ibuprofen increase perioperative blood loss during hip arthroplasty?

European journal of anaesthesiology·2002
Same author

Predictive performance of a physiological model for enflurane closed-circuit anaesthesia: effects of continuous cardiac output measurements and age-related solubility data.

British journal of anaesthesia·2002
Same journal

The Time-out.

Anesthesiology·2026
Same journal

Evaluation of Post-block Hypersensitivity Using Quantitative Sensory Testing Before, During, and After Axillary Brachial Plexus Block Resolution in Healthy Volunteers.

Anesthesiology·2026
Same journal

The state of medical education research in Anesthesiology: Current landscape and future directions - An initiative of the Anesthesia Research Council.

Anesthesiology·2026
Same journal

Diagnostic Ultrasound-guided Focused Ultrasound-induced Noninvasive, Reversible Peripheral Nerve Blockade in an In Vivo Model of Acute Pain: A Proof-of-Concept Study.

Anesthesiology·2026
Same journal

S-Ketamine Reduces Risk of Postoperative Delirium: Comment.

Anesthesiology·2026
Same journal

Computed Tomography-Based Body Composition Assessment for Preoperative Cardiovascular Risk Prediction: A Prospective Cohort Study.

Anesthesiology·2026
See all related articles

This study introduces a new computer model for simulating inhalation anesthesia using a special-purpose simulation language (SPSL). The model accurately reproduces anesthetic uptake, aiding clinical, teaching, and research applications.

Area of Science:

  • Anesthesiology
  • Computational Biology
  • Pharmacokinetics

Background:

  • Simulating inhalational anesthetic pharmacokinetics requires advanced programming skills.
  • Existing models often assume constant alveolar concentrations and do not fully represent circulation.
  • A need exists for accessible tools to model complex anesthetic processes.

Purpose of the Study:

  • To develop a custom computer program for simulating anesthetic uptake, distribution, and elimination.
  • To overcome programming barriers using a special-purpose simulation language (SPSL).
  • To create a novel, validated model for closed-circuit inhalation anesthesia.

Main Methods:

  • Utilized the block-structured SPSL TUTSIM to construct a linear, 14-compartment model.

Related Experiment Videos

  • Incorporated blood pools to mimic circulation times, deviating from constant alveolar concentration assumptions.
  • Developed advanced model variants simulating feedback control, nitrous oxide uptake, and drug interactions.

    • Main Results:

    • The model successfully reproduced experimental nitrous oxide uptake data.
    • Advanced features allowed simulation of isoflurane feedback, nitrous oxide uptake, and enflurane's cardiac output effects.
    • Concatenated variants demonstrated concentration and second-gas effects.

    Conclusions:

    • The developed SPSL model provides a robust tool for simulating closed-circuit inhalation anesthesia.
    • This approach bypasses complex programming, enabling focus on physiological modeling.
    • The validated model holds potential for clinical, educational, and research applications in anesthesiology.