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Related Experiment Video

Updated: Jul 4, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Palm-sized biodetection system based on localized surface plasmon resonance.

Pavel Neuzil1, Julien Reboud

  • 1Institute of Microelectronics, 11 Science Park Road, Singapore Science Park II, Singapore 117685. pavel@ime.a-star.edu.sg

Analytical Chemistry
|July 2, 2008
PubMed
Summary

A portable, battery-powered biodetection system utilizes localized surface plasmon resonance (LSPR) for sensitive measurements. This compact device is ideal for point-of-care and field use without external power or computers.

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Area of Science:

  • Nanotechnology and Sensor Development
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Localized Surface Plasmon Resonance (LSPR) offers high sensitivity for biodetection.
  • Existing LSPR systems often require bulky components like spectrum analyzers and external power.
  • Miniaturization is crucial for enabling portable and field-deployable diagnostic tools.

Purpose of the Study:

  • To develop a compact, battery-operated biodetection system using LSPR.
  • To replace traditional spectrum analyzers with simpler, lower-power components.
  • To demonstrate the system's suitability for point-of-care and field applications.

Main Methods:

  • A palm-sized system was designed integrating an LSPR chip.
  • Four light-emitting diodes (LEDs) with distinct spectra replaced the spectrum analyzer.

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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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Published on: November 23, 2015

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Last Updated: Jul 4, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
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Published on: March 20, 2015

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

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  • A single photodiode detected reflected light, with signals demultiplexed by a lock-in amplifier.

    • Main Results:

    • The system successfully detected varying concentrations of ethanol/water and 2-propanol/water mixtures.
    • Performance was validated using the LSPR chip with the tested solutions.
    • The device operates independently, requiring no external power supply or personal computer.

    Conclusions:

    • A miniaturized, self-contained LSPR biodetection system was successfully developed.
    • The system's design enables sensitive and portable chemical sensing.
    • This technology is well-suited for rapid diagnostics in point-of-care and field settings.