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Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
Redox Titration: Iodimetry and Iodometry01:23

Redox Titration: Iodimetry and Iodometry

Iodometry and iodimetry are analytical methods used to determine the concentration of oxidizing or reducing agents using iodine. In iodometric titrations, the oxidizing analyte solution is usually acidified and treated with an excess of iodide ions, which generates an equivalent amount of iodine in equilibrium with triiodide. The released iodine is subsequently titrated directly against a standardized reducing agent. As the dilute iodine color becomes pale yellow, a few drops of freshly...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

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Related Experiment Video

Updated: Jul 4, 2026

Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction
08:00

Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction

Published on: April 10, 2026

Iodine: deficiency and therapeutic considerations.

Lyn Patrick1

  • 1Southwest College of Naturopathic Medicine, USA. lpatrick@frontier.net

Alternative Medicine Review : a Journal of Clinical Therapeutic
|July 2, 2008
PubMed
Summary

Therapeutic iodine doses, even above the safe upper limit, show no toxicity in Japanese populations. High iodine intake may play a role in breast health and antioxidant functions.

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Public Health

Background:

  • Iodine deficiency is a leading preventable cause of mental retardation and endocrinopathy, particularly critical during pregnancy.
  • The established safe upper limit for iodine intake is 1 mg daily.
  • High iodine consumption in Japan has not shown increased incidence of thyroid dysfunction or autoimmune thyroiditis.

Purpose of the Study:

  • To evaluate the safety and potential benefits of therapeutic iodine doses exceeding the established upper limit.
  • To explore the role of iodine in maintaining breast tissue health and function.
  • To investigate iodine's potential antioxidant properties.

Main Methods:

  • Review of epidemiological data from Japanese populations with high iodine intake.

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An Efficient Method for Selective Desalination of Radioactive Iodine Anions by Using Gold Nanoparticles-Embedded Membrane Filter
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An Efficient Method for Selective Desalination of Radioactive Iodine Anions by Using Gold Nanoparticles-Embedded Membrane Filter

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Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
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Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography

Published on: May 16, 2014

Related Experiment Videos

Last Updated: Jul 4, 2026

Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction
08:00

Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction

Published on: April 10, 2026

An Efficient Method for Selective Desalination of Radioactive Iodine Anions by Using Gold Nanoparticles-Embedded Membrane Filter
07:28

An Efficient Method for Selective Desalination of Radioactive Iodine Anions by Using Gold Nanoparticles-Embedded Membrane Filter

Published on: July 13, 2018

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
10:14

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography

Published on: May 16, 2014

  • Analysis of studies investigating therapeutic doses of iodine (3.0–6.0 mg) for fibrocystic breast disease.
  • Examination of iodine's mechanism of action via the sodium iodide symporter.

    • Main Results:

    • Japanese populations consuming significantly higher iodine levels exhibit no demonstrable increase in hypothyroidism or autoimmune thyroiditis.
    • Therapeutic doses of iodine have shown efficacy in treating fibrocystic breast disease, suggesting a role in breast tissue health.
    • Iodine demonstrates potential antioxidant functions in tissues that actively transport it.

    Conclusions:

    • Therapeutic iodine doses above the current safe upper limit appear safe, as evidenced by Japanese population data.
    • Iodine plays a crucial role in maintaining normal breast tissue architecture and function.
    • Iodine possesses antioxidant properties beneficial for various tissues, including breast tissue.