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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Cortical atrophy and personality in multiple sclerosis.

Ralph H B Benedict1, Sarah Hussein, Jessica Englert

  • 1Department of Neurology, State University of New York at Buffalo, School of Medicine, New York, USA. benedict@buffalo.edu

Neuropsychology
|July 2, 2008
PubMed
Summary

Multiple sclerosis (MS) patients with brain atrophy show personality changes, specifically reduced Extraversion and Conscientiousness. These findings link neurological changes to altered personality traits in MS.

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Area of Science:

  • Neurology
  • Neuropsychology
  • Psychiatry

Background:

  • Cognitive impairment in multiple sclerosis (MS) is well-documented.
  • Personality changes in MS are less understood but may mirror those in Alzheimer's disease.
  • The Five Factor Model provides a framework for assessing personality in neurological conditions.

Purpose of the Study:

  • To investigate the association between personality changes and neocortical volume in multiple sclerosis (MS).
  • To determine if cortical atrophy correlates with specific alterations in the Five Factor Model personality traits.

Main Methods:

  • Forty-four MS patients underwent brain MRI and completed the NEO Five-Factor Inventory.
  • Regression analyses controlled for T2 lesion volume, depression, and cognitive dysfunction.
  • Discrepancies between patient and informant personality reports were analyzed.

Main Results:

  • Cortical atrophy significantly correlated with reduced Extraversion and Conscientiousness, even after controlling for confounding factors.
  • Patients tended to overreport Openness and Conscientiousness, which was linked to lower neocortical volume.
  • Personality factors, depression, and cognitive function explained 38% of the variance in neocortical volume.

Conclusions:

  • Cortical atrophy in MS is associated with significant negative impacts on personality traits.
  • Further longitudinal research is required to establish causality and track personality changes over time in MS patients.