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Updated: Jul 4, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease

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Published on: April 29, 2007

GDNF therapy for Parkinson's disease.

Murray Hong¹, Karim Mukhida, Ivar Mendez

¹Cell Restoration Laboratory, Departments of Anatomy & Neurobiology & Surgery (Neurosurgery), Dalhousie University, Room 12H1, 5850 College Street, Halifax, Nova Scotia, Canada B3H 1X5.

Expert Review of Neurotherapeutics

|July 2, 2008

Summary

Glial cell line-derived neurotrophic factor (GDNF) shows promise for protecting and regenerating dopamine neurons in Parkinson's disease (PD). Further clinical research is needed to confirm its therapeutic potential for PD treatment.

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Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

Area of Science:

Neuroscience
Neurodegenerative Disorders
Pharmacology

Background:

Parkinson's disease (PD) incidence is rising with an aging population, posing healthcare challenges.
Current PD treatments offer symptomatic relief but no cure.
Experimental evidence suggests Glial cell line-derived neurotrophic factor (GDNF) may protect and regenerate dopamine neurons in PD.

Purpose of the Study:

To review experimental and clinical evidence of GDNF in Parkinson's disease.
To evaluate GDNF's potential as an effective therapy for PD.

Main Methods:

Review of experimental studies on GDNF neuroprotection and regeneration in PD models.
Analysis of clinical trial data for GDNF infusion in PD patients.

Main Results:

Experimental studies indicate GDNF's neuroprotective and regenerative capabilities for dopamine neurons.
Clinical trials using GDNF infusion for PD have yielded inconclusive results to date.

Conclusions:

GDNF demonstrates potential for treating Parkinson's disease based on preclinical data.
Further investigation is required to clarify GDNF's efficacy and optimal delivery in clinical settings for PD.