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Updated: Jul 4, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Recurrent and multiple bladder tumors show conserved expression profiles.

David Lindgren1, Sigurdur Gudjonsson, Kowan Ja Jee

  • 1Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. david.lindgren@med.lu.se

BMC Cancer
|July 2, 2008
PubMed
Summary
This summary is machine-generated.

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Recurrent urothelial carcinoma (bladder cancer) tumors show similar expression profiles despite genetic differences. This suggests early-established expression patterns are maintained throughout tumor development and recurrence.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Urothelial carcinomas are bladder cancers that can appear as single or multiple tumors.
  • Recurrences are common after treatment, necessitating patient follow-up.
  • The genetic origins of multiple and recurrent tumors are complex and do not always follow chronological appearance.

Purpose of the Study:

  • To investigate the genetic relationship and expression profiles of metachronous and synchronous urothelial tumors.
  • To understand the evolutionary patterns of bladder cancer tumors within individual patients.

Main Methods:

  • Analysis of 49 tumors from 22 patients.
  • Utilized expression profiling, comparative genomic hybridization (CGH), loss of heterozygosity (LOH) analysis, and mutation analyses.

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Last Updated: Jul 4, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
08:43

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

Main Results:

  • Genomic alterations like chromosomal losses and mutations present in initial tumors may be absent in recurring tumors.
  • Loss of heterozygosity patterns can differ, with smaller regions affected in recurring tumors.
  • Despite genomic variations, recurrent and multiple tumors from the same patient exhibit highly similar expression profiles.

Conclusions:

  • Metachronous and synchronous urothelial tumors likely do not originate directly from preceding tumors.
  • Established tumor expression profiles appear to be stable and maintained in recurring tumors.
  • Expression profiling may serve as an early indicator of tumor development and behavior.