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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
[Prevalence of and predisposing factors for bundle branch block in patients starting dialysis]
Eduardo Vázquez Ruiz de Castroviejo1, Carmen Sánchez Perales, Juana López López
1Servicio de Cardiología, Complejo Hospitalario de Jaén, Jaén, España. vazquez89@arrakis.es
Insights
Bundle branch block (BBB) affects 11.4% of patients starting dialysis, a higher prevalence than in the general population. Older age and obesity are linked to BBB, with left BBB indicating a poorer prognosis.
Area of Science:
- Cardiology
- Nephrology
- Epidemiology
Context:
- Bundle branch block (BBB) is a common cardiac finding, but its prevalence in dialysis patients is largely unknown.
- Understanding BBB prevalence and associated factors in this high-risk population is crucial for cardiovascular risk assessment.
Purpose:
- To determine the prevalence of complete bundle branch block (BBB) in patients initiating dialysis.
- To identify clinical, biochemical, and echocardiographic factors associated with BBB in this cohort.
- To explore the association of BBB with mortality and cardiovascular events in patients starting dialysis.
Summary:
- A study of 211 patients starting dialysis found a BBB prevalence of 11.4% (6.0% left BBB, 8.5% right BBB).
- Independent predictors of BBB included older age (OR=1.05) and higher body mass index (OR=1.12).
- Over a mean follow-up of 23.7 months, left BBB showed a trend towards poorer outcomes.
Impact:
- The prevalence of BBB is significantly higher in patients starting dialysis compared to the general population.
- Older age and obesity are key factors associated with BBB in dialysis patients.
- Left BBB may serve as an indicator of poor prognosis in patients initiating renal replacement therapy.
Introduction And Objectives:
Although bundle branch block (BBB) is regarded as a frequent finding, data on its prevalence are scarce in the general population and nonexistent in patients on dialysis. The aims of this study were to determine the prevalence of complete BBB in patients starting dialysis, to identify factors associated with its presence and, secondarily, to explore its association with mortality and the occurrence of cardiovascular events.
Methods:
The study involved patients who started dialysis at our institution between November 1, 2003 and December 31, 2006. All underwent cardiological evaluation at the start of treatment. The presence of BBB was determined and its relationship with clinical factors and biochemical and echocardiographic parameters was examined. Patients were followed up until November 30, 2007.
Results:
The study included 211 patients (age 65.05+/-15.7 years; 56.4% male). Of these, 24 (11.4%) presented with BBB: 6 (2.8%) with left BBB and 18 (8.5%) with right BBB. Age (odds ratio [OR]=1.05; 95% confidence interval [CI], 1.008-1.113; P=.02) and body mass index (OR=1.12; 95% CI, 1.019-1.234; P=.02) were independently associated with BBB. During a mean follow-up period of 23.7+/-12.9 months, patients who presented with left BBB showed a clear trend towards a poorer outcome than those without a conduction defect.
Conclusions:
The prevalence of BBB was high in patients starting dialysis and greater than that observed in the general population. Its presence was independently associated with older age and obesity. During the mean follow-up period of 2 years, patients with left BBB demonstrated a trend towards a poor prognosis.
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