Related Experiment Video
Updated: Jul 4, 2026

Electrophoretic Mobility Shift Assay (EMSA) for the Study of RNA-Protein Interactions: The IRE/IRP Example
Published on: December 3, 2014
The double life of Irs
Rebecca A Haeusler1, Domenico Accili
1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.
Abstract:
The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et al., 2008; Dong et al., 2008) on the insulin-signaling adaptors Irs1 and Irs2 prompt a critical reappraisal of the physiology of fasting and of the integrated control of hepatic insulin action.
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