Pedal squamous cell carcinoma in an immunocompromised host

Area of Science:

• Dermatology
• Oncology
• Infectious Diseases

Background:

• Squamous cell carcinoma (SCC) is a prevalent skin cancer, often linked to sun exposure but can occur on the foot.
• Immunocompromised individuals and those with a history of human papilloma virus (HPV) infection face increased SCC risk.
• Lower extremity SCC, particularly on the foot, warrants attention due to potential links with HPV.

Observation:

• This report details the case of an immunocompromised patient with multiple comorbidities presenting with SCC on the left foot.
• The SCC lesion was surgically excised, followed by histopathological analysis.
• The case underscores the importance of considering SCC in atypical locations for at-risk populations.

Findings:

• The study discusses the epidemiology and diagnostic approaches for SCC.
• Histopathological analysis confirmed the diagnosis of squamous cell carcinoma.
• The case illustrates the successful surgical management of a foot SCC lesion.

Implications:

• Further research into specific HPV genotypes and immune competence measurements is crucial.
• Enhanced understanding can improve clinical and surgical management strategies for SCC, especially in high-risk patients.
• This case contributes to the literature on SCC presentation and management in immunocompromised individuals with comorbidities.