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Updated: Jul 4, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Understanding peripartum cardiomyopathy, 2008
Abstract:
Although the exact etiology of peripartum cardiomyopathy (PPCM) is still unknown, the inciting factor(s) appears to initiate an inflammatory cardiomyopathy that transitions to an autoimmune or immune dysfunctional process leading to severe heart failure in the peripartum. Early diagnosis and effective treatment, including diuretics, ACE-inhibitors, and beta-blockers, leads to improvement in most and eventual left ventricular systolic recovery in over half of patients. Additional evaluations and potential non-conventional treatments for non-responders may include research protocol use of apheresis, intravenous gamma globulin, immunoadsorption, other immunomodulation therapy, and possible anti-viral therapy.
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