Which dopamine receptor(s) do we need for motor function? Lessons from gene targeting and translational blockade

Recent advances in molecular biology have led not only to the identification of novel dopamine receptor subtypes, but also to the ability to selectively suppress the expression of these receptors. The approaches used to suppress receptor expression, as well as the problems in interpretation of the results are summarized. To date, these studies have confirmed the critical role for D2 receptors and the dopamine transporter in normal motor function, but the contributions of other receptor subtypes have not yet been adequately assessed.