Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium administration and phosphate excretion.

J A Arruda, J M Richardson, J A Wolfson

    The American Journal of Physiology
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Using BpyAla to generate copper artificial metalloenzymes: a catalytic and structural study.

    Catalysis science & technology·2024
    Same author

    The Liver Treatment of Pernicious Anæmia.

    The Indian medical gazette·2017
    Same author

    An Unusually Large Horny Growth.

    The Indian medical gazette·2017
    Same author

    Fluoxetine induces lean phenotype in rat by increasing the brown/white adipose tissue ratio and UCP1 expression.

    Journal of bioenergetics and biomembranes·2015
    Same author

    Physico-chemical confinement of helical nanofilaments.

    Soft matter·2015
    Same author

    Bronchial carcinoid tumor presenting with recurrent pneumothorax.

    Revista portuguesa de pneumologia·2014

    Lithium administration in dogs blunts the phosphaturic effects of parathyroid hormone (PTH) and cyclic adenosine monophosphate (cAMP). This suggests lithium interferes with renal cAMP signaling pathways, impacting phosphate excretion.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Pharmacology

    Background:

    • Parathyroid hormone (PTH) regulates phosphate (PO4) excretion.
    • Cyclic adenosine monophosphate (cAMP) is a key intracellular mediator of PTH action.
    • Lithium (Li) is known to affect renal function and cellular signaling.

    Purpose of the Study:

    • To investigate the effect of lithium on the phosphaturic response to PTH, cAMP, acetazolamide, and bicarbonate loading in dogs.
    • To determine if lithium's effects on phosphate excretion are mediated solely through the adenyl cyclase-cAMP system.

    Main Methods:

    • Experiments were conducted in normal, thyroparathyroidectomized (TPTX), and lithium-treated dogs.
    • Fractional excretion of phosphate (FPO4), sodium (FNa), and bicarbonate (FHCO3) were measured after administration of PTH, cAMP, acetazolamide (Az), or bicarbonate loading.

    Related Experiment Videos

    Main Results:

    • PTH and cAMP administration markedly increased FPO4 in normal dogs but had a blunted effect in lithium-treated dogs.
    • Acetazolamide increased FNa, FHCO3, and FPO4 in normal dogs, but only natriuresis and bicarbonaturia in lithium-treated dogs.
    • Bicarbonate loading induced phosphaturia in normal dogs but not in lithium-treated dogs, and a lower FPO4 in TPTX dogs compared to normal dogs.

    Conclusions:

    • Lithium administration significantly diminishes the phosphaturic effects of PTH and cAMP in the renal cortex.
    • These findings suggest that lithium interferes with the adenyl cyclase-cAMP system and may also affect downstream signaling pathways involved in phosphate excretion.
    • Lithium's impact on renal phosphate handling extends beyond the adenyl cyclase-cAMP pathway.