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Updated: Jul 4, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
Prospective evaluation of parkinsonism and tremor in patients treated with valproate
M Nouzeilles1, M García, A Rabinowicz
1Movement Disorders Section, Raul Carrea Institute for Neurological Research, (FLENI), Montañeses 2325, (1428) Buenos Aires, Argentina.
Abstract:
We observed a high incidence of postural and intentional tremor in patients exposed to VPA, although not strong enough to interfere with normal life. l-dopa unresponsive parkinsonism was recorded in 10% of patients who received VPA treatment. No correlation with gender, dosage, duration of treatment or concomitant administration of other antiepileptic drugs was observed. The mechanisms for such side effects are unclear. As new GABA mimetic drugs have been postulated to be useful in tremor control [8], it remains paradoxical that VPA should exacerbate such symptomatology by means of a similar mechanism of action.
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