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Updated: Jul 4, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Genetic predisposition plays a role in nigral cell death in Parkinson's disease
1Axys Pharmaceuticals, Suite 160, 11099 N Torrey Pines, La Jolla, CA 93037, USA; Barrow Neurological Institute, Phoenix, AZ, USA.
Abstract:
Both genetic and environmental factors are involved in the etiology of Parkinson's disease (PD). The recent identification of specific autosomal genes that lead to variants of PD confirms that genetic factors are important. Identifying and confirming other genetic factors responsible for PD is a difficult task because PD is a complex disease, the results of multiple genetic and environmental factors leading to a final common pathology. This review will discuss how advances in human genetics will allow future unraveling of the complex interactions between genetics and environment in the etiology of PD.
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