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Published on: May 31, 2016
Clinical outcome of unilateral stereotactic pallidotomy without microelectrode recording for intractable Parkinson's
R B Dewey1, C A Giller, S K Broline
1Department of Neurology, UT Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75235-9036, USA.
Objective:
To study the effects of unilateral stereotactic pallidotomy performed without microelectrode recording for advanced Parkinson's disease.
Methods:
Stereotactic coordinates were calculated by comparing preoperative inversion recovery MRI sequences with intraoperative CT scans. Conventional stereotactic stimulation techniques were employed to confirm correct probe placement. Patients were assessed using a modified CAPIT protocol with the off-state UPDRS motor score as the primary efficacy measure.
Results:
A statistically significant decline in off-state UPDRS motor scores occurred at 2months (21% improvement in 32 patients) and also at 1year postoperatively (30% improvement in 12 patients). Levodopa-induced dyskinesias on the side contralateral to surgery were reduced 97% in the cohort with 1year of follow-up. No deleterious effects of surgery on global neuropsychological functioning were seen. A major surgical complication (mild but persistent hemiparesis) occurred in one patient.
Conclusions:
We believe that stereotactic pallidotomy can be performed safely and effectively without microelectrode recording when coordinates are calculated using CT with comparison to preoperative MRI sequences.
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