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Molecular imaging in drug development.

Jürgen K Willmann¹, Nicholas van Bruggen, Ludger M Dinkelborg

¹The Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5427, USA.

Nature Reviews. Drug Discovery

|July 2, 2008

Summary

Molecular imaging non-invasively assesses biological processes for drug development. This review highlights its successes and challenges in oncology to improve candidate selection and development decisions.

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Area of Science:

Biomedical imaging
Pharmacology
Oncology

Background:

Molecular imaging enables non-invasive study of biological and biochemical processes in vivo.
Understanding disease and drug activity is crucial for effective drug development.
Oncology drug development faces challenges in candidate selection and failure prediction.

Purpose of the Study:

To review the applications of molecular imaging in drug development, particularly in oncology.
To highlight successful uses of molecular imaging in preclinical and clinical drug development.
To identify key challenges hindering the integration of molecular imaging into the drug development pipeline.

Main Methods:

Literature review focusing on molecular imaging applications in oncology drug development.
Analysis of case studies demonstrating successful integration of molecular imaging.
Identification of common challenges and limitations in current molecular imaging practices.

Main Results:

Molecular imaging aids in assessing drug efficacy and target engagement non-invasively.
Successful applications include early prediction of treatment response and patient stratification.
Key challenges involve standardization, cost, and data interpretation.

Conclusions:

Molecular imaging offers significant potential to optimize oncology drug development.
Addressing current challenges is essential for broader adoption and success.
Further research and technological advancements are needed to fully realize its benefits.