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Updated: Jul 4, 2026

In Vivo EPR Assessment of pH, pO2, Redox Status, and Concentrations of Phosphate and Glutathione in the Tumor Microenvironment
Published on: March 16, 2018
In Vivo EPR For Dosimetry
Harold M Swartz1, Greg Burke, M Coey
1Dartmouth Medical School, EPR Center for the Study of Viable Systems, Hanover, NH USA.
Electron Paramagnetic Resonance (EPR) in vivo tooth dosimetry offers a rapid method for assessing radiation exposure. This technique aids in immediate medical decisions for individuals exposed to ionizing radiation.
Area of Science:
- Medical Physics
- Radiation Dosimetry
- Biophysics
Background:
- Accidental or intentional exposure to ionizing radiation necessitates rapid dose assessment for clinical management.
- Accurate individual dosimetry is crucial for differentiating those requiring immediate medical intervention from those who do not.
Purpose of the Study:
- To evaluate in vivo Electron Paramagnetic Resonance (EPR) measurements of radiation-induced changes in tooth enamel as a method for individual radiation dose assessment.
Main Methods:
- Utilized in vivo EPR spectroscopy to measure radiation-induced paramagnetic centers in tooth enamel.
- Developed and tested a portable EPR system for immediate post-exposure dose estimation.
Main Results:
- The in vivo EPR dosimeter can estimate absorbed radiation dose with approximately +/- 50 cGy error for acute biological effects.
- The method differentiates radiation doses sufficiently for classifying individuals for medical treatment.
Conclusions:
- In vivo EPR tooth dosimetry is a promising method for rapid, accurate assessment of radiation exposure in emergency scenarios.
- Ongoing technological advancements aim to improve precision, speed, and portability for wider clinical application.
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