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Updated: Jul 4, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
[Positive influence on cardiovascular risk factor by blocking the endocannabinoid system]
1HerzZentrum Hirslanden Zentralschweiz, Hirslanden Klinik St. Anna, Luzern. tushar.chatterjee@hirslanden.ch
Abstract:
Intra-abdominal fat mass, or central adiposity, and cardiovascular risk are strongly correlated. Adipose tissue is an endocrine organ that secretes hormones and cytokines influencing appetite, energy metabolism, and atherosclerosis. Rimonabant is the first selective blocker of the cannabinoid-1 receptor in development for the treatment of obesity, diabetes mellitus typ 2, and cardiometabolic risk factors. This article provides an review of efficacy of rimonabant the first selective blocker of the cannabinoid-1 receptor.
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