Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence, patterns and motives for hormonal contraceptive use among German servicewomen: results from a nationwide survey.

Frontiers in endocrinology·2026
Same author

The overload loop: a distinct reoxygenation pattern above the second ventilatory threshold revealed by a new analytical method.

Biology of sport·2026
Same author

Lower cardiopulmonary resuscitation quality after pre-resuscitation physical exertion and stress exposure in active firefighters: a within-subject field study in a standardized operational setting.

Resuscitation plus·2026
Same author

Optimizing High-Intensity Functional Training Performance: Individualized Load Prescription vs. Standardized Weights.

Sports (Basel, Switzerland)·2026
Same author

Larger-volume capillary blood sampling is a valid alternative to assess progesterone and 17ß-estradiol for cycle phase identification in tactical female athletes.

Frontiers in physiology·2026
Same author

Virtual stress testing: Analyzing endocrine, metabolic, cardiovascular, and psychological responses to the TSST-VR.

Neurobiology of stress·2025

Related Experiment Video

Updated: Jul 4, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

CD7(-) T cells are late memory cells generated from CD7(+) T cells.

Gunter Rappl1, David Schrama, Andreas Hombach

  • 1Tumorgenetics, Department of Internal Medicine I, University of Cologne, Cologne, Germany.

Rejuvenation Research
|July 3, 2008
PubMed
Summary

CD7(-) T cells are identified as aging T cells with reduced function and increased susceptibility to cell death. These cells, characterized by KLRG-1 expression and shorter telomeres, develop from CD7(+) T cells after repeated stimulation.

More Related Videos

Murine Superficial Lymph Node Surgery
04:36

Murine Superficial Lymph Node Surgery

Published on: May 21, 2012

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

Related Experiment Videos

Last Updated: Jul 4, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Murine Superficial Lymph Node Surgery
04:36

Murine Superficial Lymph Node Surgery

Published on: May 21, 2012

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

Area of Science:

  • Immunology
  • Cell Biology
  • Aging Research

Background:

  • CD7(-) T cells are a distinct subset of CD4(+) and CD8(+) T cells.
  • Their developmental origin and functional relationship to CD7(+) T cells were previously unclear.

Purpose of the Study:

  • To elucidate the developmental and functional characteristics of CD7(-) T cells.
  • To understand their relationship with CD7(+) T cells and their role in T cell aging.

Main Methods:

  • Flow cytometry to identify T cell subsets.
  • Analysis of molecular markers associated with T cell aging (KLRG-1, telomere length, telomerase activity, TRECs).
  • In vitro differentiation of naive T cells and in vivo clonal expansion analysis.

Main Results:

  • CD7(-) T cells represent aging T cells with a high activation threshold, low effector function, and increased sensitivity to activation-induced cell death (AICD).
  • These cells exhibit high KLRG-1 expression, shorter telomeres, decreased telomerase expression, and fewer TRECs compared to CD7(+) T cells.
  • In vitro studies showed CD7(-) T cells are generated from naive CD7(+) T cells through repetitive TCR/CD28 stimulation and multiple cell divisions.
  • In vivo, CD7(-) T cell clonal expansions are less frequent and traceable to CD7(+) T cell precursors.

Conclusions:

  • CD7(-) T cells are terminally differentiated, aged T cells.
  • Their generation is an unidirectional process linked to T cell division and activation history.
  • This finding clarifies the fate of T cells undergoing extensive proliferation and activation.