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Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
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Bimodal electric tissue ablation: positive electrode studies.

Christopher Dobbins1, Catriona Brennan, Simon A Wemyss-Holden

  • 1University of Adelaide Discipline of Surgery, Institute of Medical and Veterinary Science, The Queen Elizabth Hospital, Adelaide, South Australia, Australia.

ANZ Journal of Surgery
|July 3, 2008
PubMed
Summary

Increasing the positive electrode surface area during bimodal electric tissue ablation significantly increases ablation size. This method, using a scalpel blade, achieved larger lesions than standard radiofrequency ablation with minimal tissue injury risk.

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Area of Science:

  • Medical Devices
  • Surgical Technology
  • Electrophysiology

Background:

  • Bimodal electric tissue ablation is a novel technique enhancing standard radiofrequency ablation with direct electrical current.
  • A potential risk of electrolytic injury at the positive electrode site can occur.
  • Increasing the positive electrode surface area may mitigate tissue injury.

Purpose of the Study:

  • To test the hypothesis that increasing the positive electrode surface area reduces tissue injury during bimodal electric tissue ablation.
  • To evaluate the impact of electrode configuration on ablation size and tissue damage in a porcine liver model.

Main Methods:

  • Thirty-six liver ablations were performed in six pigs.
  • Experimental groups included standard radiofrequency ablation (controls), positive electrode on a scalpel blade, and positive electrode on a grounding pad.
  • Ablation sizes were measured, and skin biopsies were histopathologically examined.

Main Results:

  • Scalpel blade and grounding pad ablations were significantly larger than controls (P < 0.001).
  • Scalpel blade group showed significantly larger ablations compared to the grounding pad group.
  • Scalpel blade site exhibited full-thickness skin injury, while the grounding pad site showed no microscopic damage.

Conclusions:

  • Increasing the positive electrode surface area significantly enhances ablation size in bimodal electric tissue ablation.
  • Utilizing a larger surface area, such as a scalpel blade, maximizes ablation volume while minimizing associated tissue injury risks.