Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic ulcerative stomatitis.

L W Solomon1

  • 1Department of Oral and Maxillofacial Pathology, Tufts University School of Medicine, Boston, MA 02111-1527, USA. lynn.solomon@tufts.edu

Oral Diseases
|July 3, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tp63 in oral development, neoplasia, and autoimmunity.

Journal of dental research·2011
Same author

ELISA test for p63 antibodies in chronic ulcerative stomatitis.

Oral diseases·2009
Same author

Autoimmunity to deltaNp63alpha in chronic ulcerative stomatitis.

Journal of dental research·2007
Same author

Percutaneous suture closure for management of large French size arterial puncture in aortic valvuloplasty.

The Journal of invasive cardiology·2001
Same author

Left ventricular aneurysmectomy in advanced left ventricular dysfunction.

Cardiology clinics·1995
Same author

Linear left ventricular aneurysmectomy: modern imaging studies reveal improved morphology and function.

The Annals of thoracic surgery·1993
Same journal

Authors' Reply "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
Same journal

Neutrophils From Aged Individuals Release NETs to Impair Oral Wound Healing Through NLRP3 Activation.

Oral diseases·2026
Same journal

Comment on "Multimodal Deep Learning-Based Screening of Degenerative Temporomandibular Joint Disease Using 2D Radiography: A Cost-Effective and Low-Radiation Approach".

Oral diseases·2026
Same journal

Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches.

Oral diseases·2026
Same journal

Comment on "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
Same journal

Atypical Whitish Gingival Plaque.

Oral diseases·2026
See all related articles

Chronic ulcerative stomatitis (CUS) is a rare oral condition affecting middle-aged women. Diagnosis requires biopsy and immunofluorescence, as treatments like hydroxychloroquine are more effective than glucocorticoids.

Area of Science:

  • Oral pathology
  • Immunodermatology
  • Autoimmune diseases

Background:

  • Chronic ulcerative stomatitis (CUS) is a distinct oral condition.
  • Characterized by painful erosions and ulcerations.
  • Histopathology often mimics oral lichen planus (OLP).

Purpose of the Study:

  • To describe the immunopathologic findings in CUS.
  • To highlight diagnostic challenges and treatment considerations.
  • To explore the etiology and pathogenesis of CUS.

Main Methods:

  • Surgical biopsy for histopathology.
  • Direct and indirect immunofluorescence microscopy.
  • Identification of autoantibodies via immunofluorescence.

Main Results:

Related Experiment Videos

  • CUS affects white women in late middle age.
  • Histology shows non-specific chronic inflammation.
  • Autoantibodies to DeltaNp63alpha are detected in circulation and tissue.

Conclusions:

  • Accurate CUS diagnosis is crucial due to limited glucocorticoid efficacy.
  • Hydroxychloroquine shows therapeutic benefit.
  • Etiology and pathogenesis remain unknown, necessitating further research.