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Overview of Systemic Arteries01:11

Overview of Systemic Arteries

The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the heart.
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Chronic Inflammation: Introduction

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Genome-wide Association Studies-GWAS01:11

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Aneurysm I: Introduction01:30

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Updated: Jul 4, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Giant cell arteritis: a systemic vascular disease.

Federico Tatò1, Ulrich Hoffmann

  • 1Division of Vascular Medicine, Ludwig Maximilians University Hospital, Pettenkoferstrasse 8a, D-80336 [corrected] Munich, Germany. Federico.Tato@t-online.de

Vascular Medicine (London, England)
|July 3, 2008
PubMed
Summary

Giant cell arteritis (GCA) is a systemic vascular disease affecting peripheral arteries and the aorta, leading to complications like limb ischemia and aneurysms. Advanced imaging aids in early diagnosis and management of this large-vessel vasculitis.

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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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07:37

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Published on: May 14, 2013

Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Immunology

Background:

  • Giant cell arteritis (GCA) is increasingly understood as a systemic vasculitis.
  • It affects not only cranial arteries but also peripheral arteries and the aorta.
  • Peripheral vascular complications occur in up to one-third of GCA patients.

Purpose of the Study:

  • To highlight the systemic nature of GCA beyond cranial arteries.
  • To emphasize the prevalence and consequences of peripheral and aortic involvement.
  • To discuss the role of advanced vascular imaging in diagnosing and managing GCA.

Main Methods:

  • Review of epidemiological studies on GCA complications.
  • Analysis of clinical presentations of peripheral and aortic GCA.
  • Evaluation of advancements in vascular imaging techniques (ultrasound, CT, MRI, 18F-FDG-PET).

Main Results:

  • GCA frequently involves large- and medium-sized peripheral arteries, causing lumen occlusion and limb ischemia.
  • Aortic GCA significantly increases the risk of aneurysms and dissections, especially in the thoracic aorta.
  • Improved imaging techniques enhance the detection and study of arterial changes in GCA.

Conclusions:

  • GCA is a systemic disease with significant peripheral and aortic manifestations.
  • Early diagnosis and management by vascular specialists are crucial.
  • Advanced imaging plays a vital role in understanding and treating large-vessel vasculitis.