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Interleukin-4 blocks parathyroid hormone-related protein-induced hypercalcemia in vivo
K Nagasaki1, K Yamaguchi, K Watanabe
1Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan.
Biochemical and Biophysical Research Communications
|July 31, 1991
Abstract:
Interleukin (IL)-4 inhibits bone resorption. In the present study, the effect of IL-4 on hypercalcemia in nude mice under two experimental conditions was assessed. IL-4 inhibited plasma calcium elevation induced by parathyroid hormone-related protein (PTHrP) infusion. In hypercalcemic nude mice bearing PTHrP-producing tumors, IL-4 lowered plasma calcium levels to almost the normal range. These results indicate that IL-4 blocks PTHrP-induced hypercalcemia in vivo.