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Ba2+ current oscillation evoked by bradykinin in ras-transformed fibroblasts
H Higashida1, N Hoshi, M Hashii
1Department of Biophysics, Kanazawa University School of Medicine, Japan.
Biochemical and Biophysical Research Communications
|July 31, 1991
Abstract:
By voltage-clamp recording, we show a novel inward current which oscillates after activation with bradykinin or serum in v-Ki-ras-transformed NIH/3T3 cells. The current oscillation was infrequently observed in control NIH/3T3 fibroblasts. The same stimulation evokes Ca2+ oscillations in the ras-transformed cells but not in parental cells (Fu et al., FEBS Lett. 281, 263-266, 1991). The results suggest that the oscillatory currents are generated by influxes of divalent cations to maintain Ca2+ oscillations in ras-transformed NIH/3T3 cells.