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Endoscopic and histopathologic findings associated with H. pylori infection in very young children

Engin Tutar1, Deniz Ertem, Esin Kotiloglu Karaa

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara University School of Medicine, Tophanelioglu Cd. 13-15, 81190, Altunizade, Istanbul, Turkey.

Digestive Diseases and Sciences
|July 3, 2008
PubMed

Insights

Helicobacter pylori (H. pylori) infection in infants often leads to gastritis, even without clear symptoms. Long-term complications in endemic areas warrant careful monitoring of infected infants.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Microbiology

Background:

  • Helicobacter pylori (H. pylori) is a common bacterial infection acquired early in life.
  • Limited data exists on endoscopic and histopathologic findings of H. pylori in infants.
  • Understanding early-life infection is crucial for long-term health outcomes.

Purpose of the Study:

  • To investigate H. pylori-related endoscopic and histopathologic findings in infants under two years old.
  • To determine the prevalence and characteristics of H. pylori infection in this age group.
  • To assess the correlation between H. pylori density and gastritis severity.

Main Methods:

  • Retrospective analysis of 152 infants undergoing upper gastrointestinal endoscopy.
  • H. pylori diagnosis confirmed by histopathology and rapid urease test.
  • Evaluation of endoscopic and histopathologic findings, including gastritis presence and severity.

Main Results:

  • H. pylori infection was diagnosed in 26.3% (40/152) of infants.
  • 65% of infected infants presented with histopathologic gastritis.
  • No specific clinical or endoscopic findings were indicative of H. pylori infection.
  • No correlation was found between H. pylori density and gastritis severity.

Conclusions:

  • H. pylori infection in infants is frequently associated with gastritis, even in the absence of overt symptoms.
  • The high prevalence of histopathologic gastritis suggests potential long-term implications.
  • Close follow-up of infected infants is recommended in H. pylori endemic regions.

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