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Theoretical development and performance evaluation for extractive fermentation using multiple extractants.

Z Shi¹, K Shimizu, S Iijima

¹Department of Chemical Engineering, Nagoya University, Chikusa, Nagoya 464-01, Japan.

Biotechnology and Bioengineering

|August 20, 1990

Summary

This summary is machine-generated.

Using multiple solvents in extractive fermentation, like oleyl alcohol and benzyl benzoate, significantly boosts acetone-butanol fermentation productivity and product concentration compared to single-solvent methods.

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Area of Science:

Biochemical Engineering
Separation Processes
Fermentation Technology

Background:

Extractive fermentation enhances product recovery by using a solvent to remove the target compound during fermentation.
Optimizing solvent use is crucial for improving the efficiency and economics of fermentation processes.
Acetone-butanol fermentation is a key bioprocess for producing valuable chemicals, but product inhibition limits its performance.

Purpose of the Study:

To develop a mathematical framework for evaluating extractive fermentation performance with multiple solvents.
To investigate the impact of different solvent-supplying strategies on fermentation outcomes.
To assess the potential for performance enhancement in acetone-butanol fermentation using multiple extractants.

Main Methods:

Mathematical modeling was employed to formulate the performance evaluation of extractive fermentation.
Two distinct solvent-supplying strategies were analyzed: simultaneous addition and consecutive addition.
Computer simulations were conducted for batch, fed-batch, and repeated fed-batch operations of acetone-butanol fermentation.

Main Results:

The study demonstrates that using multiple solvents, specifically oleyl alcohol and benzyl benzoate, leads to significant improvements.
Performance gains were observed in terms of both productivity and final product concentration.
The mathematical formulation and simulation approach proved effective in predicting performance enhancements.

Conclusions:

The use of multiple solvents in extractive fermentation offers a promising strategy for enhancing bioprocess efficiency.
Simultaneous or consecutive addition of solvents can be tailored to optimize product recovery and concentration.
This approach is particularly beneficial for challenging fermentations like acetone-butanol production, paving the way for more economical biomanufacturing.