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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

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Updated: Jul 4, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

[Inflammatory cloacogenic polyp].

Roberto Calva-Rodríguez1, Mario Alberto González-Palafox, María Eugenia Rivera-Domínguez

  • 1Facultad de Medicina, Benemérita Universidad Autónoma de Puebla.

Revista De Gastroenterologia De Mexico
|July 4, 2008
PubMed
Summary
This summary is machine-generated.

Cloacogenic polyps, inflammatory lesions in the lower rectum, can affect young adults and infants. Prompt diagnosis via biopsy is crucial to differentiate these rare polyps from colorectal cancers.

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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

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Last Updated: Jul 4, 2026

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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Area of Science:

  • Gastroenterology
  • Pediatric Pathology

Background:

  • Cloacogenic polyps present as inflammatory lesions in the lower rectum and anal transition zone.
  • These polyps can prolapse due to internal anal sphincter malfunction, often resulting from chronic inflammation.
  • While more common in women aged 30-40, lesions occur across a wide age range, typically located above the anal verge.

Observation:

  • A 10-year-old female presented with a 3-month history of abdominal pain, vomiting, constipation, and diarrhea.
  • The patient's symptoms suggest a potential gastrointestinal issue requiring investigation.

Findings:

  • Cloacogenic polyps are rare, often affecting young adults but also seen in infants.
  • The lesions are sessile, 3-4 cm in diameter, and predominantly located on the anterior-lateral wall.
  • Histopathological analysis is essential for definitive diagnosis.

Implications:

  • The presence of cloacogenic polyps in infants necessitates their inclusion in differential diagnoses for rectal masses.
  • These lesions can be misdiagnosed as colorectal malignant tumors due to their characteristics.
  • Biopsy and histopathology are critical for all pediatric patients with rectal masses and hematochezia to determine lesion origin.