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Grapefruit pulp increases antioxidant status and improves bone quality in orchidectomized rats
Farzad Deyhim1, Kranthi Mandadi, Bhimanagouda S Patil
1Department of Human Sciences, Texas A&M University-Kingsville, Kingsville, Texas, USA. Farzad.Deyhim@tamuk.edu
Nutrition (Burbank, Los Angeles County, Calif.)
|July 4, 2008
Summary
Grapefruit pulp (GP) consumption improved antioxidant status and bone quality in orchidectomized rats, reducing osteoporosis risk. This study highlights GP
Area of Science:
- Nutritional Science
- Endocrinology
- Bone Biology
Background:
- Orchidectomy (ORX) induces oxidative stress and osteoporosis.
- Maintaining bone health after ORX is a significant clinical challenge.
Purpose of the Study:
- To investigate the effects of grapefruit pulp (GP) on antioxidant status and osteoporosis in ORX rats.
- To determine if GP consumption can mitigate the negative effects of orchidectomy on bone.
Main Methods:
- Male Sprague-Dawley rats underwent orchidectomy (ORX) or sham surgery.
- ORX rats were fed diets with 0%, 5%, or 10% GP for 60 days.
- Evaluated plasma antioxidant status, bone turnover markers, bone mineral content, and bone quality.
Main Results:
- ORX significantly decreased antioxidant status, bone quality, and mineral content while increasing bone turnover markers.
- GP consumption, irrespective of dose, improved antioxidant status, bone density, and delayed femoral fracture.
- GP intake lowered fecal calcium and urinary deoxypyridinoline excretion, dose-dependently slowed bone turnover, and increased bone calcium and magnesium.
Conclusions:
- Grapefruit pulp consumption beneficially impacts bone quality in orchidectomized rats.
- These effects are attributed to enhanced bone mineral deposition and reduced bone turnover.
- GP shows potential as a dietary intervention for managing osteoporosis post-orchidectomy.