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Related Experiment Videos

Trans-cellular migration: cell-cell contacts get intimate.

Christopher V Carman1, Timothy A Springer

  • 1Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. ccarman@bidmc.harvard.edu

Current Opinion in Cell Biology
|July 4, 2008
PubMed
Summary
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Trans-cellular migration, where one cell moves through another, is a newly recognized process in leukocyte trafficking. Emerging evidence highlights its significant physiological role in cell biology.

Area of Science:

  • Cell Biology
  • Immunology
  • Physiology

Background:

  • Trans-cellular migration, a cell moving directly through another, is counterintuitive and not widely accepted.
  • Reported for decades in leukocyte transendothelial migration, it's often omitted from diapedesis accounts.
  • Recent studies provide new in vitro and in vivo evidence for this phenomenon.

Purpose of the Study:

  • To investigate the mechanisms of trans-cellular diapedesis.
  • To highlight the physiological significance of trans-cellular migration in leukocyte trafficking.
  • To provide updated evidence supporting trans-cellular migration as a key biological process.

Main Methods:

  • In vitro and in vivo observations of cell migration.
  • Elucidation of cellular mechanisms involved in trans-cellular diapedesis.

Related Experiment Videos

  • Analysis of leukocyte and endothelial cell interactions.

    • Main Results:

    • Podosome-like protrusive activities in leukocytes were identified as a key mechanism.
    • Specific fusogenic functions in endothelial cells were implicated in the process.
    • Evidence suggests trans-cellular migration significantly contributes to leukocyte trafficking.

    Conclusions:

    • Trans-cellular migration is an important and physiological cell biological process.
    • Mechanisms involving leukocyte protrusions and endothelial cell fusion are crucial.
    • This process plays a significant role in leukocyte trafficking in various settings.