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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Tumor necrosis factor and interferon: cytokines in harmony
Eric Bartee1, Mohamed R Mohamed, Grant McFadden
1Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Current Opinion in Microbiology
|July 4, 2008
Summary
Certain combinations of tumor necrosis factor (TNF) and interferons create a unique synergistic antiviral state. This combined effect offers broader virus inhibition than individual cytokines, highlighting a significant immune response mechanism.
Area of Science:
- Immunology
- Virology
- Cellular Biology
Background:
- Tumor necrosis factor (TNF) and interferons are known for their individual antiviral properties.
- The combined effect of these cytokines on antiviral states has been less explored.
Purpose of the Study:
- To investigate the synergistic antiviral state induced by combinations of TNF and interferons.
- To understand the mechanisms and scope of this combined antiviral activity.
Main Methods:
- Experimental combination of TNF and interferons.
- Assessment of antiviral state induction.
- Analysis of affected viral ranges and signaling pathways.
Main Results:
- Specific cytokine combinations induce a synergistic antiviral state distinct from individual treatments.
- This synergistic state inhibits a wider spectrum of viruses.
- Multiple signaling pathways are involved in this enhanced response.
Conclusions:
- The combination of TNF and interferons generates a potent, synergistic antiviral state.
- This phenomenon has broader implications for anti-pathogen responses than previously recognized.
- Further research is needed to fully elucidate the mechanisms and physiological relevance.
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