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Related Concept Videos

Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...

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Related Experiment Video

Updated: Jul 4, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

Update on irritable bowel syndrome and gender differences.

Margaret M Heitkemper1, Monica E Jarrett

  • 1Department of Biobehavioral Nursing, University of Washington, Seattle, WA 98195, USA. heit@u.washington.edu

Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
|July 4, 2008
PubMed
Summary

Irritable bowel syndrome (IBS) is a common gut disorder causing pain and altered bowel habits. This review explores IBS causes, why women are more affected, and current treatments for symptom relief.

Related Experiment Videos

Last Updated: Jul 4, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

Area of Science:

  • Gastroenterology
  • Functional Gastrointestinal Disorders

Background:

  • Irritable bowel syndrome (IBS) is a prevalent chronic functional gastrointestinal disorder.
  • It is characterized by abdominal pain linked to changes in bowel habits and stool consistency.
  • Women are more frequently diagnosed with IBS and seek healthcare services for symptoms compared to men.

Purpose of the Study:

  • To provide an overview of IBS pathogenesis.
  • To examine factors contributing to observed gender differences in IBS prevalence and presentation.
  • To summarize current therapeutic strategies for managing IBS symptoms.

Main Methods:

  • This is a review article, synthesizing existing research on IBS.
  • Literature search on the pathophysiology, gender-specific factors, and treatments of IBS.
  • Analysis of current management approaches, including behavioral and pharmacological therapies.

Main Results:

  • IBS etiology is multifactorial, involving altered gut motility, visceral hypersensitivity, and autonomic nervous system dysregulation.
  • Diet and stress are common symptom exacerbators, with women reporting symptom fluctuations related to their menstrual cycle.
  • Management strategies encompass dietary modifications, stress reduction techniques, and pharmacologic interventions targeting pain, motility, and secretion.

Conclusions:

  • Understanding the multifactorial nature of IBS and gender-specific factors is crucial for effective management.
  • Current therapeutic approaches offer symptomatic relief but require personalized application.
  • Further research into the underlying mechanisms and gender-specific pathways may lead to improved IBS treatments.