Related Experiment Video
Updated: Jul 4, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
Multiple vaccinations, health, and recall bias within UK armed forces deployed to Iraq: cohort study
Dominic Murphy1, Matthew Hotopf, Simon Wessely
1King's Centre for Military Health Research, King's College London SE5 9RJ. dominic.murphy@iop.kcl.ac.uk
Objective:
To assess the relation between self reported number of vaccinations received and health, and between numbers of vaccinations recorded from individuals' medical records and health.
Design:
First phase of a cohort study.
Setting:
UK armed forces personnel.
Participants:
4882 randomly selected military personnel deployed to Iraq since 2003 and a subset of 378 whose vaccination records were accessed.
Main Outcome Measures:
Psychological distress, fatigue, symptoms of post-traumatic stress disorder, health perception, and multiple physical symptoms.
Results:
Personnel who reported receiving two or more vaccinations on a single day were more likely to report symptoms of fatigue (adjusted risk ratio 1.17, 95% confidence interval 1.05 to 1.30), show caseness according to the general health questionnaire (1.31, 1.13 to 1.53), and have multiple physical symptoms (1.32, 1.08 to 1.60). These associations were no longer significant when number of vaccinations recorded in individuals' medical records was used as the independent variable.
Conclusions:
Multiple vaccinations given to personnel in the UK armed forces in preparation for deployment to Iraq are not associated with adverse health consequences when vaccinations are recorded objectively from medical records. Adverse health consequences associated with self reported multiple vaccinations could be explained by recall bias.
Related Concept Videos
Vaccinations
Bias in Epidemiological Studies
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
The Availability Heuristic
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Bioavailability Study Design: Healthy Subjects Versus Patients
