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Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Related Experiment Video

Updated: Jul 4, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Activated stat-3 in melanoma.

Jane L Messina1, Hua Yu, Adam I Riker

  • 1Pathology Service, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. jane.messina@moffitt.org

Cancer Control : Journal of the Moffitt Cancer Center
|July 4, 2008
PubMed
Summary
This summary is machine-generated.

Activated Stat-3 signaling is increased in melanoma, particularly in metastatic lesions, while Stat-1 shows less activity. This suggests a potential role for Stat-3 in melanoma progression.

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • The Src-Stat pathway is implicated in melanoma development.
  • Investigating phosphorylated Stat-3 (pStat-3), activated Stat-1 (pStat-1), and interferon alpha receptor subunit 1 (IFNAR-1) in melanocytic neoplasms is crucial.

Purpose of the Study:

  • To examine the expression of pStat-3, pStat-1, and IFNAR-1 in various human melanocytic lesions.
  • To determine the correlation between these markers and the progression of melanoma.

Main Methods:

  • Immunohistochemistry was used to evaluate pStat-1, pStat-3, and IFNAR-1 expression.
  • Specimens included benign nevi, primary melanoma, and metastatic melanoma.
  • Staining intensity and percentage of positive tumor cells were scored.

Main Results:

  • Benign nevi showed minimal expression of pStat-1, pStat-3, and IFNAR-1.
  • Activated Stat-3 was found in primary melanoma and frequently in metastatic melanoma.
  • Melanoma tumors exhibited high levels of either pStat-3 or pStat-1, not both, with cytoplasmic IFNAR-1 staining present in all melanoma specimens.

Conclusions:

  • Increased Stat-3 activity is observed in melanoma compared to benign nevi.
  • The inverse correlation between pStat-3 and pStat-1 levels warrants further investigation.
  • The role of activated Stat-3 in the biological behavior of melanocytic lesions requires further study.