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VEGF-targeted therapy: mechanisms of anti-tumour activity

Lee M Ellis1, Daniel J Hicklin

  • 1Department of Surgical Oncology, Unit 444, University of Texas M.D. Anderson Cancer Center, PO Box 301402, Houston, Texas 77230-1402, USA. lellis@mdanderson.org

Nature Reviews. Cancer
|July 4, 2008
PubMed

Insights

Vascular endothelial growth factor (VEGF)-targeted therapies show benefits in advanced cancers. Their complex mechanisms, beyond starving tumors, require further study for improved clinical use.

Area of Science:

  • Oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Vascular endothelial growth factor (VEGF)-targeted agents are used in advanced malignancies.
  • These therapies were designed to inhibit tumor angiogenesis by restricting blood supply.

Purpose of the Study:

  • To explore the complex mechanisms of VEGF-targeted therapy.
  • To identify how a deeper understanding can advance clinical applications.

Main Methods:

  • Review of existing data on VEGF-targeted agents.
  • Analysis of therapeutic benefits and underlying mechanisms.

Main Results:

  • VEGF-targeted therapies offer benefits in advanced cancers, alone or with chemotherapy.
  • The therapeutic benefit is more complex than initially thought, involving multiple mechanisms.

Conclusions:

  • Understanding the multifaceted mechanisms of VEGF-targeted therapy is crucial.
  • Further research into these mechanisms will drive future clinical advancements in cancer treatment.

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