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Updated: Jul 4, 2026
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Imprinting of molecular recognition sites through electropolymerization of functionalized Au nanoparticles:
Michael Riskin1, Ran Tel-Vered, Tatyana Bourenko
1Institute of Chemistry, Center for Nanoscience, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Abstract:
Electrochemical sensors for the analysis of TNT with enhanced sensitivities are described. The enhanced sensitivities are achieved by tailoring pi-donor-acceptor interactions between TNT and pi-donor-modified electrodes or pi-donor-cross-linked Au nanoparticles linked to the electrode. In one configuration a p-aminothiophenolate monolayer-modified electrode leads to the analysis of TNT with a sensitivity corresponding to 17 ppb (74 nM). In the second configuration, the cross-linking of Au NPs by oligothioaniline bridges to the electrode yields a functionalized electrode that detects TNT with a sensitivity that corresponds to 460 ppt (2 nM). Most impressively, the imprinting of molecular TNT recognition sites into the pi-donor oligoaniline-cross-linked Au nanoparticles yields a functionalized electrode with a sensitivity that corresponds to 46 ppt (200 pM). The electrode reveals high selectivity, reusability, and stability.
