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Regulation of APC/C activators in mitosis and meiosis

Jillian A Pesin1, Terry L Orr-Weaver

  • 1Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

Annual Review of Cell and Developmental Biology
|July 5, 2008
PubMed

Insights

The anaphase-promoting complex/cyclosome (APC/C) regulates cell division. This review details APC/C regulation during mitosis and its specific roles and controls in female meiosis.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The anaphase-promoting complex/cyclosome (APC/C) is a crucial E3 ubiquitin ligase controlling mitosis.
  • APC/C activators, Cdc20 and Cdh1, dictate substrate specificity and are tightly regulated.
  • Meiosis requires modified APC/C activity for accurate chromosome segregation.

Purpose of the Study:

  • To review the regulation of APC/C activators during mitosis.
  • To explore the role and regulation of the APC/C during female meiosis.
  • To highlight meiosis-specific APC/C regulators.

Main Methods:

  • Literature review of existing studies on APC/C regulation.
  • Analysis of regulatory mechanisms including protein degradation, phosphorylation, and inhibitory binding.
  • Focus on mitotic and meiosis-specific regulatory pathways.

Main Results:

  • APC/C activity is modulated by various mechanisms during mitosis.
  • Meiosis-specific activators and regulators fine-tune APC/C function for female meiosis.
  • Both conserved mitotic regulators and unique meiosis-specific factors control APC/C in meiosis.

Conclusions:

  • Understanding APC/C regulation is vital for comprehending cell division.
  • Meiosis-specific regulation of APC/C is essential for proper female gamete formation.
  • This review synthesizes current knowledge on APC/C control in mitosis and female meiosis.

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