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Published on: April 11, 2016
Emerging DNA sequencing technologies for human genomic medicine
Robert L Strausberg1, Samuel Levy, Yu-Hui Rogers
1J. Craig Venter Institute, Rockville, MD 20850, USA. RLS@jcvi.org
Drug Discovery Today
|July 5, 2008
Summary
Next-generation sequencing technologies are crucial for advancing genomic medicine. These innovations will make whole genome sequencing a standard in research and patient care for personalized health strategies.
Area of Science:
- Genomics
- Biomedical Research
- Medical Technology
Background:
- The Human Genome Project demonstrated the power of automated DNA sequencing using Sanger technology.
- Current sequencing methods face limitations for widespread clinical application.
- Advancements are needed to integrate whole genome sequencing into routine healthcare.
Purpose of the Study:
- To review emerging DNA sequencing technologies.
- To highlight technologies enabling the future of genomic medicine.
- To discuss the potential impact of personalized genomics on preventative medicine and patient care.
Main Methods:
- Review of current and developing DNA sequencing technologies.
- Analysis of advancements in high-throughput sequencing.
- Literature synthesis on the applications of whole genome sequencing.
Main Results:
- Several promising DNA sequencing technologies are in early development.
- These technologies aim to significantly increase speed and reduce costs of genome sequencing.
- The potential for comprehensive genomic data in clinical decision-making is substantial.
Conclusions:
- Emerging sequencing technologies are poised to revolutionize biomedical research and patient care.
- Whole genome sequencing is expected to become a standard tool, driving genomic medicine.
- Personalized preventative strategies based on individual genomes will become increasingly feasible.
Related Concept Videos
03:00Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
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