Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
¹H NMR Signal Integration: Overview00:58

¹H NMR Signal Integration: Overview

The intensity of a signal, which can be represented by the area under the peak, depends on the number of protons contributing to that signal. The area under each peak is shown as a vertical line called an integral, with the integral value listed under it, as seen in the proton NMR spectrum of benzyl acetate. Each integral value is divided by the smallest integral value to obtain the ratio of the number of protons producing each signal. The ratio reveals the relative number of protons and not...
Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
Application of Integration: Problem Solving01:30

Application of Integration: Problem Solving

The process of breathing involves the periodic intake and expulsion of air, known as the respiratory cycle, which typically lasts about five seconds. Modeling the volume of air inhaled into the lungs as a function of time provides insight into both the dynamics and efficiency of pulmonary ventilation. This volume is determined by integrating the airflow rate over time, which captures the cumulative effect of air entering the lungs.Sinusoidal Model of AirflowAirflow during respiration is not...
Integrated Healthcare System01:20

Integrated Healthcare System

An integrated healthcare system (IHS) is a set of organizations that provides for or arranges to provide coordinated and continuous service to a defined population. The IHS takes responsibility for that particular population's health status and outcome, both clinically and fiscally. An integrated healthcare system is a well-organized, well-coordinated, and collaborative network. The integrated delivery system is a network that connects different healthcare providers to deliver organized,...
Distribution Reliability and Automation01:25

Distribution Reliability and Automation

Distribution reliability in electrical power systems is critical for ensuring an uninterrupted power supply to consumers at minimal cost. According to IEEE Standard Terms, reliability is the probability that a device will function without failure over a specified time period or amount of usage. For electric power distribution, this translates to maintaining continuous power supply and addressing customer concerns over power outages. Several indices, as defined by IEEE Standard 1366-2012, are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addendum: The FAIR Guiding Principles for scientific data management and stewardship.

Scientific data·2019
Same author

The FAIR Guiding Principles for scientific data management and stewardship.

Scientific data·2016
Same author

Recent advances in modeling languages for pathway maps and computable biological networks.

Drug discovery today·2014
Same author

Causal reasoning on biological networks: interpreting transcriptional changes.

Bioinformatics (Oxford, England)·2012
Same author

Predictive networks: a flexible, open source, web application for integration and analysis of human gene networks.

Nucleic acids research·2011
Same author

Empowering industrial research with shared biomedical vocabularies.

Drug discovery today·2011
Same journal

Inorganic nanoparticles for diagnostics, drug delivery and therapy for solid tumors.

Drug discovery today·2026
Same journal

HDAC11 as a potential therapeutic target for Alzheimer's disease.

Drug discovery today·2026
Same journal

From biologics to small-molecule modulators: The evolving landscape of interleukin-targeted therapeutics.

Drug discovery today·2026
Same journal

Targeting the GLP-1 receptor pathways for dual management of obesity and depression.

Drug discovery today·2026
Same journal

Chemical intervention strategies targeting MYC for cancer therapy.

Drug discovery today·2026
Same journal

How many protein pairs can we chemically target?

Drug discovery today·2026
See all related articles

Related Experiment Video

Updated: Jul 3, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

Beyond data integration.

Ted Slater1, Christopher Bouton, Enoch S Huang

  • 1Pfizer Worldwide Technology, Chesterfield, MO 63017, USA.

Drug Discovery Today
|July 5, 2008
PubMed
Summary
This summary is machine-generated.

Pharmaceutical companies struggle to use vast experimental data for drug discovery. This review proposes an integrated platform for efficient data interpretation to predict drug efficacy and safety.

Related Experiment Videos

Last Updated: Jul 3, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

Area of Science:

  • Drug discovery and development
  • Computational biology
  • Pharmacology

Background:

  • Pharmaceutical R&D generates massive datasets, hindering effective use for predicting drug efficacy and safety.
  • Existing data integration methods often fail to provide actionable insights due to interpretation challenges.

Purpose of the Study:

  • To propose a novel, interoperable platform for pharmaceutical data analysis.
  • To enhance the prediction of drug mechanism, efficacy, and safety.
  • To overcome the limitations of current data integration and interpretation.

Main Methods:

  • Knowledge engineering for data organization and representation.
  • Hypothesis generation algorithms for data-driven insights.
  • Integration of experimental data with expert knowledge.

Main Results:

  • The proposed platform aims to rapidly assess confidence in drug mechanism and safety.
  • Enables more effective utilization of experimental data and expert knowledge.
  • Facilitates quicker decision-making in drug development programs.

Conclusions:

  • An integrated platform combining knowledge engineering and hypothesis generation is crucial for pharmaceutical R&D.
  • This approach addresses the challenge of data overload and interpretation.
  • It promises to accelerate the prediction of drug efficacy and safety.