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Oral Drug Delivery Systems: Introduction

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

Drug Delivery Systems: Different Types

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

Oral Drug Delivery Systems: Delayed-Release Systems

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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Updated: Jul 3, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms.

Bo Tang¹, Gang Cheng, Jian-Chun Gu

¹Shenyang Pharmaceutical University, Shenyang City 110016, Liaoning Province, People's Republic of China. tangbobox@126.com

Drug Discovery Today

|July 5, 2008

Summary

Solid self-emulsifying drug delivery systems (S-SEDDS) offer an improved alternative to liquid formulations for enhancing hydrophobic drug bioavailability. This review covers S-SEDDS solidification techniques and future research directions.

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Published on: September 20, 2017

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Last Updated: Jul 3, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Materials Science

Background:

Poor aqueous solubility affects approximately 40% of new chemical entities, leading to low bioavailability.
Conventional liquid self-emulsifying drug delivery systems (SEDDS) present formulation and administration challenges.
Solid SEDDS (S-SEDDS) emerge as a promising alternative to overcome limitations of liquid SEDDS.

Purpose of the Study:

To provide a comprehensive overview of recent advancements in solid self-emulsifying drug delivery systems (S-SEDDS).
To highlight various solidification techniques employed in S-SEDDS preparation.
To discuss the development of solid self-emulsifying (SE) dosage forms and future research avenues.

Main Methods:

Review of current literature on S-SEDDS.
Analysis of different solidification techniques for preparing S-SEDDS.
Examination of solid SE dosage form development and challenges.

Main Results:

S-SEDDS effectively improve the bioavailability of hydrophobic drugs by solidifying liquid/semisolid SE ingredients into powders.
Various solidification techniques are available for S-SEDDS development, offering advantages over conventional liquid SEDDS.
Progress has been made in developing stable and effective solid SE dosage forms.

Conclusions:

S-SEDDS represent a significant advancement in drug delivery for poorly soluble compounds.
Further research is needed to address existing challenges and optimize S-SEDDS technology.
Continued exploration of solidification techniques and solid SE dosage forms will enhance therapeutic outcomes.