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Updated: Jul 3, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Present perspectives on flaviviral chemotherapy.

Debapriya Ghosh¹, Anirban Basu

¹National Brain Research Centre, Manesar, Haryana 122050, India.

Drug Discovery Today

|July 5, 2008

Summary

Flaviviruses cause severe diseases like encephalitis and hemorrhagic fever. This review explores current drug research, highlighting the urgent need for new chemotherapeutic agents to combat these global arbovirus threats.

Area of Science:

Virology
Infectious Diseases
Drug Discovery

Background:

Flaviviruses are arboviruses causing significant global health issues, including neurotrophic disorders and hemorrhagic fevers.
Periodic outbreaks and emergence in new areas due to climate change necessitate urgent development of new treatments.
Existing vaccines are limited, and no definitive chemotherapeutic cure for flaviviral infections is available.

Purpose of the Study:

To review the current landscape of chemotherapeutic agents explored for flaviviral infections.
To identify promising avenues for future flavivirus drug discovery.
To provide perspectives on ameliorating or abrogating flaviviral diseases.

Main Methods:

Comprehensive literature review of existing flavivirus drug research.

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Last Updated: Jul 3, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

Analysis of chemotherapeutic agents investigated to date.

Exploration of potential future drug targets and strategies.

Main Results:

A significant gap exists in effective chemotherapeutic treatments for flaviviral diseases.
Various agents have been explored, but none offer an absolute cure.
The review synthesizes current knowledge and identifies research gaps.

Conclusions:

There is an urgent need for novel chemotherapeutic agents against flaviviruses.
Further research into drug discovery is critical to combat emerging flaviviral threats.
Future breakthroughs may offer improved disease management and potential cures.