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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Is Our Natural-history Model Of Lung Cancer Wrong?
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Is Our Natural-history Model Of Lung Cancer Wrong?

    • Related Experiment Videos

    Is our natural-history model of lung cancer wrong?

    Peter B Bach1

    • 1Health Outcomes Group, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. bachp@mskcc.org

    The Lancet. Oncology
    |July 5, 2008

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Lung cancer screening aims to find early-stage disease, but studies suggest these early cancers may not be precursors to fatal outcomes. This challenges current screening models and future development strategies.

    Related Experiment Videos

    Area of Science:

    • Oncology
    • Public Health

    Background:

    • Lung cancer screening programs aim to reduce mortality by detecting early-stage disease.
    • Current screening strategies are based on the assumption that early-stage lung cancer is localized and treatable.

    Purpose of the Study:

    • To evaluate the validity of the natural-history model of lung cancer used in current screening programs.
    • To assess whether early-stage lung cancers detected by screening are indeed precursors to advanced or fatal disease.

    Main Methods:

    • Review of empirical findings from lung cancer screening studies.
    • Analysis of the natural-history model of lung cancer in the context of screening.

    Main Results:

    • Emerging evidence from screening studies suggests that early-stage lung cancers identified are not precursors of advanced or incurable disease.
    • The presumed precursor of fatal lung cancer may not be accurately identified by current screening methods.

    Conclusions:

    • The current natural-history model underpinning lung cancer screening may be flawed.
    • These findings necessitate a re-evaluation of lung cancer screening approaches and the development of new strategies.